Bodybuilding Supplement PEGylated Mechano Growth Factor PEG MGF 2mg
MGF is a splice variant of the IGF gene which increases stem cell
count in the muscle and allows for muscle fibers to fuse and
This is a process required for growth of adult muscle. Natural MGF
is made locally and does not travel into the bloodstream.
Synthetic MGF is water based and when administered intramuscularly,
travels into the bloodstream. MGF is only stable in the blood
stream for only a few minutes.
PEGylation is the act of attaching a Polyethylene glycol (PEG)
structure to another larger molecule (in this case, MGF).
The PEG acts as a protective coating and the theory here is that
this will allow the MGF to be carried through the blood stream
without being broken down.
MGF is produced biologically when muscle fibers are broken down
through resistance (weight training). It is a potent factor in
MGF stimulates muscle growth, creates new muscle fibers, promotes
nitrogen retention and increases protein synthesis.
The Effects of Pegylated MGF
Mechano Growth Factor (MGF) exhibits local effects in skeletal
muscle and without cannot travel through the body without
modification. The problem with synthetic Mechano Growth Factor
(MGF) is that it is introduced intramuscularly and is water based
so it goes into the blood stream. When used this way, Mechano
Growth Factor (MGF) only remains stable in the blood stream for a
few minutes. Biologically produced MGF is made locally and does not
enter the bloodstream. It is also short acting so stability is not
an issue. By PEGylating the Mechano Growth Factor (MGF) it is
almost as efficient as local produced Mechano Growth Factor (MGF)
when used intramuscularly. This is accomplished by surrounding part
of the peptide with a structure of polyethylene glycol, which can
be attached to a protein molecule. The polyethylene glycol groups
protect the peptide but do not surround it completely. The active
sites of the peptide are still free to do their biological
function. In this case the shell is a negative charged shield
against positively charged compounds that would affect the protein.